Francis de Zegher Selected Research

Hirsutism

10/2017	Normalizing Ovulation Rate by Preferential Reduction of Hepato-Visceral Fat in Adolescent Girls With Polycystic Ovary Syndrome.
1/2017	An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence.
1/2014	Hyperinsulinaemic androgen excess in adolescent girls.
5/2013	Oral contraception vs insulin sensitization for 18 months in nonobese adolescents with androgen excess: posttreatment differences in C-reactive protein, intima-media thickness, visceral adiposity, insulin sensitivity, and menstrual regularity.
11/2011	Treatment of androgen excess in adolescent girls: ethinylestradiol-cyproteroneacetate versus low-dose pioglitazone-flutamide-metformin.
8/2011	Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence.
8/2010	Therapy: Low-dose flutamide for hirsutism: into the limelight, at last.
5/2007	Combined low-dose pioglitazone, flutamide, and metformin for women with androgen excess.
6/2003	Low-dose flutamide-metformin therapy reverses insulin resistance and reduces fat mass in nonobese adolescents with ovarian hyperandrogenism.

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Francis de Zegher Research Topics

Disease

34	Insulin Resistance 07/2022 - 01/2002
15	Birth Weight (Birth Weights) 01/2017 - 01/2002
13	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 05/2020 - 02/2002
12	Obesity 01/2022 - 07/2005
10	Hyperandrogenism 07/2010 - 06/2003
9	Inflammation (Inflammations) 01/2022 - 04/2004
9	Hirsutism 10/2017 - 06/2003
8	Hyperinsulinism (Hyperinsulinemia) 01/2019 - 01/2002
7	Body Weight (Weight, Body) 07/2022 - 06/2003
7	Weight Gain 01/2018 - 06/2004
5	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019 - 10/2007
4	Overweight 01/2021 - 10/2009
4	Oligomenorrhea 05/2020 - 06/2003
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 12/2003
4	Acne Vulgaris 01/2017 - 11/2011
4	Hyperglycemia 06/2015 - 10/2008
4	Pseudopseudohypoparathyroidism 04/2012 - 12/2008
4	Pseudohypoparathyroidism 01/2012 - 12/2008
3	Infertility (Sterility) 10/2017 - 05/2013
3	Type 2 Diabetes Mellitus (MODY) 06/2015 - 08/2007
2	Menstruation Disturbances 01/2017 - 01/2014
2	Hypertriglyceridemia 06/2015 - 04/2004
2	Hypoadiponectinemia 07/2012 - 10/2009
2	Muscular Diseases (Myopathy) 02/2010 - 03/2004
2	Dyslipidemias (Dyslipidemia) 01/2004 - 06/2003
1	Gonadoblastoma 02/2022
1	Dysgerminoma 02/2022
1	Neoplasms (Cancer) 02/2022
1	Asthma (Bronchial Asthma) 01/2022
1	Arthritis (Polyarthritis) 01/2022
1	Muscle Weakness 01/2022
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022
1	Precocious Puberty 01/2021
1	Sotos Syndrome 12/2020
1	Genetic Predisposition to Disease (Genetic Predisposition) 05/2020
1	Abdominal Obesity 05/2020
1	Lipoma (Lipomata) 01/2020
1	Critical Illness (Critically Ill) 01/2020
1	Roifman syndrome 01/2018

Drug/Important Bio-Agent (IBA)

28	Metformin (Glucophage)FDA LinkGeneric 07/2022 - 01/2003
22	Insulin (Novolin)FDA Link 01/2020 - 01/2002
18	AndrogensIBA 05/2020 - 06/2003
14	LipidsIBA 01/2021 - 06/2003
13	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 01/2002
12	Flutamide (Eulexin)FDA LinkGeneric 06/2015 - 01/2003
10	AdiponectinIBA 11/2021 - 04/2004
7	C-Reactive ProteinIBA 01/2018 - 02/2006
7	Insulin-Like Growth Factor I (IGF-1)IBA 01/2017 - 01/2002
6	Growth Hormone (Somatotropin)IBA 02/2022 - 01/2002
5	Triglycerides (Triacylglycerol)IBA 01/2022 - 09/2007
5	Hormones (Hormone)IBA 01/2017 - 06/2007
4	Pioglitazone (Actos)FDA Link 01/2021 - 06/2015
4	Oral ContraceptivesIBA 01/2021 - 01/2003
4	LeptinIBA 10/2012 - 06/2006
3	Spironolactone (Aldactone)FDA LinkGeneric 01/2021 - 01/2018
3	Contraceptive Agents (Contraceptives)IBA 01/2021 - 02/2006
3	Interleukin-6 (Interleukin 6)IBA 01/2018 - 04/2004
3	Alanine Transaminase (SGPT)IBA 06/2014 - 07/2005
3	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 07/2012 - 01/2005
3	5-phenylpent-4-enyl-1-hydroperoxideIBA 04/2012 - 12/2008
3	Dehydroepiandrosterone SulfateIBA 10/2009 - 06/2004
3	drospirenone FDA LinkGeneric 02/2006 - 04/2004
2	Growth Differentiation Factor 15IBA 01/2022 - 01/2021
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2016
2	GlucocorticoidsIBA 01/2018 - 03/2005
2	C-PeptideIBA 04/2016 - 09/2013
2	GonadotropinsIBA 01/2016 - 01/2014
2	AdipokinesIBA 06/2014 - 04/2004
2	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 06/2014 - 05/2007
2	OsteocalcinIBA 03/2014 - 07/2008
2	Estradiol (Delestrogen)FDA LinkGeneric 01/2014 - 11/2006
2	Testosterone (Sustanon)FDA Link 05/2013 - 05/2007
2	Parathyroid Hormone (Parathormone)IBA 01/2012 - 12/2010
2	Androgen Receptors (Androgen Receptor)IBA 12/2010 - 05/2007
2	Sex Hormone-Binding GlobulinIBA 10/2009 - 01/2006
2	Plasminogen Activators (Plasminogen Activator)IBA 10/2007 - 02/2002
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 05/2007 - 07/2005
2	ProinsulinIBA 01/2002 - 01/2002
1	SecretagoguesIBA 07/2022
1	Peptide Hormones (Polypeptide Hormones)IBA 07/2022
1	Leukotriene B4IBA 01/2022
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2022
1	5-methoxy-methylindoleacetic acid (DBI)IBA 11/2021
1	Immunoglobulin G (IgG)IBA 01/2021
1	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/2021
1	Immunoglobulin A (IgA)IBA 01/2021
1	A-Form DNA (A-DNA)IBA 12/2020
1	ChemokinesIBA 01/2020
1	Indicators and Reagents (Reagents)IBA 01/2020
1	hydroxide ionIBA 01/2018
1	InterleukinsIBA 01/2018
1	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2018
1	Small Nuclear RNA (snRNA)IBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2018
1	Triptorelin Pamoate (Trelstar)FDA Link 01/2018
1	alpha-2-HS-GlycoproteinIBA 01/2018

Therapy/Procedure

15	Therapeutics 01/2018 - 01/2002
3	Contraception (Birth Control) 01/2018 - 09/2005
2	Estrogen Replacement Therapy 02/2022 - 01/2016
1	Castration 02/2022